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What (who) is trephine$84858$ - definition
![[[Dr. John Clarke]] [[trepanning]] a skull, ca. 1664, in one of the earliest American portraits. Clarke has a trephine in his right hand. The painting is in [[Harvard Medical School]].<ref>[[Holmes, Oliver Wendell]] (September 18, 2008). [http://www.gutenberg.org/ebooks/2700 ''Medical Essays''].</ref><!--What page of the book? This information is not found on the cited webpage itself.-->](https://commons.wikimedia.org/wiki/Special:FilePath/Dr John Clarke trepanning a skull operation.jpg?width=200 "[[Dr. John Clarke]] [[trepanning]] a skull, ca. 1664, in one of the earliest American portraits. Clarke has a trephine in his right hand. The painting is in [[Harvard Medical School]].<ref>[[Holmes, Oliver Wendell]] (September 18, 2008). [http://www.gutenberg.org/ebooks/2700 ''Medical Essays''].</ref><!--What page of the book? This information is not found on the cited webpage itself.-->")
Wikipedia
Bone marrow examination refers to the pathologic analysis of samples of bone marrow obtained by bone marrow biopsy (often called trephine biopsy) and bone marrow aspiration. Bone marrow examination is used in the diagnosis of a number of conditions, including leukemia, multiple myeloma, lymphoma, anemia, and pancytopenia. The bone marrow produces the cellular elements of the blood, including platelets, red blood cells and white blood cells. While much information can be gleaned by testing the blood itself (drawn from a vein by phlebotomy), it is sometimes necessary to examine the source of the blood cells in the bone marrow to obtain more information on hematopoiesis; this is the role of bone marrow aspiration and biopsy.
